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IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2.

Identifieur interne : 002F00 ( Main/Exploration ); précédent : 002E99; suivant : 002F01

IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2.

Auteurs : Wayne G. Shreffler [États-Unis] ; Doerthe A. Lencer ; Ludmilla Bardina ; Hugh A. Sampson

Source :

RBID : pubmed:16210066

Descripteurs français

English descriptors

Abstract

Detailed assessment of antibody responses to allergens reveals clinically relevant information about both host response and antigen structure. Microarray technology offers advantages of scale and parallel design over previous methods of epitope mapping.

DOI: 10.1016/j.jaci.2005.06.033
PubMed: 16210066


Affiliations:


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Le document en format XML

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<term>2S Albumins, Plant</term>
<term>Allergens (genetics)</term>
<term>Allergens (immunology)</term>
<term>Amino Acid Sequence</term>
<term>Antibody Specificity</term>
<term>Antigen-Antibody Reactions</term>
<term>Antigens, Plant</term>
<term>Arachis (genetics)</term>
<term>Arachis (immunology)</term>
<term>Case-Control Studies</term>
<term>Cluster Analysis</term>
<term>Epitope Mapping (methods)</term>
<term>Epitope Mapping (statistics & numerical data)</term>
<term>Glycoproteins (genetics)</term>
<term>Glycoproteins (immunology)</term>
<term>Humans</term>
<term>Immunoglobulin E (metabolism)</term>
<term>Immunoglobulin G (metabolism)</term>
<term>In Vitro Techniques</term>
<term>Molecular Sequence Data</term>
<term>Peanut Hypersensitivity (genetics)</term>
<term>Peanut Hypersensitivity (immunology)</term>
<term>Plant Proteins (genetics)</term>
<term>Plant Proteins (immunology)</term>
<term>Protein Array Analysis</term>
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<term>Albumines 2S de plante</term>
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<term>Allergènes (immunologie)</term>
<term>Analyse de regroupements</term>
<term>Analyse par réseau de protéines</term>
<term>Antigènes végétaux</term>
<term>Arachis (génétique)</term>
<term>Arachis (immunologie)</term>
<term>Cartographie épitopique ()</term>
<term>Données de séquences moléculaires</term>
<term>Glycoprotéines (génétique)</term>
<term>Glycoprotéines (immunologie)</term>
<term>Humains</term>
<term>Hypersensibilité à l'arachide (génétique)</term>
<term>Hypersensibilité à l'arachide (immunologie)</term>
<term>Immunoglobuline E (métabolisme)</term>
<term>Immunoglobuline G (métabolisme)</term>
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<term>Protéines végétales (immunologie)</term>
<term>Réaction antigène-anticorps</term>
<term>Spécificité des anticorps</term>
<term>Séquence d'acides aminés</term>
<term>Techniques in vitro</term>
<term>Études cas-témoins</term>
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<term>2S Albumins, Plant</term>
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<term>Allergènes</term>
<term>Arachis</term>
<term>Glycoprotéines</term>
<term>Hypersensibilité à l'arachide</term>
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<term>Allergènes</term>
<term>Arachis</term>
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<term>Peanut Hypersensitivity</term>
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<term>Epitope Mapping</term>
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<term>Immunoglobuline E</term>
<term>Immunoglobuline G</term>
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<term>Epitope Mapping</term>
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<keywords scheme="MESH" xml:lang="en">
<term>Amino Acid Sequence</term>
<term>Antibody Specificity</term>
<term>Antigen-Antibody Reactions</term>
<term>Case-Control Studies</term>
<term>Cluster Analysis</term>
<term>Humans</term>
<term>In Vitro Techniques</term>
<term>Molecular Sequence Data</term>
<term>Protein Array Analysis</term>
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<term>Albumines 2S de plante</term>
<term>Analyse de regroupements</term>
<term>Analyse par réseau de protéines</term>
<term>Antigènes végétaux</term>
<term>Cartographie épitopique</term>
<term>Données de séquences moléculaires</term>
<term>Humains</term>
<term>Réaction antigène-anticorps</term>
<term>Spécificité des anticorps</term>
<term>Séquence d'acides aminés</term>
<term>Techniques in vitro</term>
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<div type="abstract" xml:lang="en">Detailed assessment of antibody responses to allergens reveals clinically relevant information about both host response and antigen structure. Microarray technology offers advantages of scale and parallel design over previous methods of epitope mapping.</div>
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